Not a practical play, but a funny one:
After exiling some of your opponent's good stuff, cast Animate Artifact on it, have it exile itself and seal them away forever.
Posted By:
Zetan
(1/29/2012 8:40:51 AM)
"Try to imagine, this a high voltage laser containment system. Simply turning them off will be like dropping a bomb on the city. "
-Dr. Egon Spengler
Posted By:
StoicChampion
(1/29/2012 10:36:22 AM)
Considering how important this particular artifact is to the story, it's interesting that it has absolutely no abilities that prevent its destruction. Of course, having any would screw with its in-game functionality, but I find it funny that an artifact that is capable of sealing demons away can be destroyed by any schmuck with a club (Manic Vandal).
Posted By:
TDL
(1/26/2012 4:43:35 PM)
Exile your etb creatures, then use Worldslayer to wipe the board.
Posted By:
zinliah
(1/26/2012 4:23:26 PM)
One of the only ways for mono red to deal with Avacyn, Angel of Hope.
Posted By:
lorendorky
(4/27/2012 12:03:02 AM)
Sweet Avacyn and Hella Vault.
Posted By:
Kwazii
(1/29/2012 5:45:14 PM)
I think what people are forgetting is that it's REPEATABLE exile. Sure, if someone pops it, they get their stuff back, but man, how many times have you bumped into a BU control deck sporting artifact removal? I'd happily pay 
to exile a Grave Titan any day.
That, and this card is just really neat, and it screams combobait. Red decks get a huge kick out of this, turning their cards like Traitorous Blood into a much more deadly threat (and they're pretty darn significant threads already). Green can ramp up to the card's more expensive ability pretty easily, and can otherwise use it as a hideaway to dump a ton of creatures in the late game for an Overrun or something similar.
Posted By:
TherealphatMatt
(2/9/2012 1:40:18 AM)
I've locked down a few games using this; it's very underrated. Most opponents won't waste their artifact removal on it, so you are saving your own creatures from death if you decide to bring them back by destroying the vault yourself later on; or if it's late-game, you're locking down your opponents by exiling each new creach they throw out. I have this and my Karn Liberated for late game win-more conditioning.
Posted By:
Arkh36
(2/19/2012 10:57:54 PM)
Its nice, when they try to spot removal your creatures if you have extra mana you can simply exile them. Later on you get an unmake on a stick at mana. They will be hesitant to pop this thing when its holding your treasures as well.
And if you happen to have a way to sac this thing yourself, then that gives you options.
Posted By:
TheWrathofShane
(3/26/2012 1:31:38 AM)
Dark Ascension: Mythics you DON'T want, and probably won't get!
win?
Posted By:
Hayw00d0909
(1/27/2012 2:41:59 PM)